Article
Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells.
Cancer cell - 1 Apr 2008
Kirstetter Peggy, Schuster Mikkel B, Bereshchenko Oksana, Moore Susan, Dvinge Heidi, Kurz Elke, Theilgaard-Mönch Kim, Månsson Robert, Pedersen Thomas A, Pabst Thomas, Schrock Evelin, Porse Bo T, Jacobsen Sten Eirik W, Bertone Paul, Tenen Daniel G, Nerlov Claus
Abstract excerpt
Mutations in the CEBPA gene are present in 7%-10% of human patients with acute myeloid leukemia (AML). However, no genetic models exist that demonstrate their etiological relevance. To mimic the most common mutations affecting CEBPA-that is, those leading to loss of the 42 kDa C/EBPalpha isoform (p42) while retaining the 30kDa isoform (p30)-we modified the mouse Cebpa locus to express only p30. p30 supported the...
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