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Article

In vivo impact of JAK3 A573V mutation revealed using zebrafish.

Cellular and molecular life sciences : CMLS - 27 May 2022

Basheer Faiza, Bulleeraz Vilasha, Ngo Viet Q T, Liongue Clifford, Ward Alister C

Abstract excerpt

BACKGROUND: Janus kinase 3 (JAK3) acts downstream of the interleukin-2 (IL-2) receptor family to play a pivotal role in the regulation of lymphoid cell development. Activating JAK3 mutations are associated with a number of lymphoid and other malignancies, with mutations within the regulatory pseudokinase domain common. METHODS: The pseudokinase domain mutations A572V and A573V were separately introduced into the...

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Identifiers

PMID: 35622134
DOI: 10.1007/s00018-022-04361-8
PMCID: PMC9142468

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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