Key roles of Arg(5), Tyr(10) and his residues in Aβ-heme peroxidase: relevance to Alzheimer's disease.

Abstract excerpt

Recent reports show that heme binds to amyloid β-peptide (Aβ) in the brain of Alzheimer's disease (AD) patients and forms Aβ-heme complexes, thus leading a pathological feature of AD. However, the important biological relevance to AD etiology, resulting from human Aβ-heme peroxidase formation, was not well characterized. In this study, we used wild-type and mutated human Aβ1-16 peptides and investigated their...

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