Article

Roles of zinc ions and structural polymorphism of β-amyloid in the development of Alzheimer’s disease

2015-03-01

Abstract excerpt

Aggregation of the β-amyloid peptide (Aβ) underlies the development of Alzheimer’s disease. The review considers the main steps of the Aβ formation and aggregation. Emphasis is placed on the interaction of zinc ions with the metal-binding domain 1–16 of Aβ as a molecular mechanism leading to Aβ aggregation. Recent studies of native modifications in the Aβ metal-binding domain revealed its structural polymorphism....

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Literature Corpus work: f9d7cb56-139c-560e-98e6-b037e3c43c5f
DOI: 10.1134/s0026893315020065

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