Article
Rat's trick to escape Alzheimer's disease.
Journal of biomolecular structure & dynamics - 1 Dec 2007
Shen Lian, Ji Hong-Fang
Abstract excerpt
Amyloid beta (Abeta) peptides fibril formation and deposition is considered to be the principal pathological hallmark of Alzheimer's disease (AD). However, it remains obscure why AD is precluded by rat/mouse despite the high sequence identity (97%) of rat/mouse Abeta to its human homologue. Based on the recently proposed redox chemistry-based pathogenic model of neurodegenerative diseases, we hypothesize that the...
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