Article
The English (H6R) Mutation of the Alzheimer's Disease Amyloid-β Peptide Modulates Its Zinc-Induced Aggregation.
Biomolecules - 25 Jun 2020
Radko Sergey P, Khmeleva Svetlana A, Kaluzhny Dmitry N, Kechko Olga I, Kiseleva Yana Y, Kozin Sergey A, Mitkevich Vladimir A, Makarov Alexander A
Abstract excerpt
The coordination of zinc ions by histidine residues of amyloid-beta peptide (Aβ) plays a critical role in the zinc-induced Aβ aggregation implicated in Alzheimer's disease (AD) pathogenesis. The histidine to arginine substitution at position 6 of the Aβ sequence (H6R, English mutation) leads to an early onset of AD. Herein, we studied the effects of zinc ions on the aggregation of the Aβ42 peptide and its isoform...
Topics
- Alzheimer Disease
- Amyloid beta-Peptides
- Humans
- Mutation
- Protein Aggregates
- Zinc