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Article

Alzheimer's Aβ peptides with disease-associated N-terminal modifications: influence of isomerisation, truncation and mutation on Cu2+ coordination.

PloS one - 30 Dec 2010

Drew Simon C, Masters Colin L, Barnham Kevin J

Abstract excerpt

BACKGROUND: The amyloid-β (Aβ) peptide is the primary component of the extracellular senile plaques characteristic of Alzheimer's disease (AD). The metals hypothesis implicates redox-active copper ions in the pathogenesis of AD and the Cu(2+) coordination of various Aβ peptides has been widely studied. A number of disease-associated modifications involving the first 3 residues are known, including isomerisation,...

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Identifiers

PMID: 21209855
DOI: 10.1371/journal.pone.0015875
PMCID: PMC3012727

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