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Article

Joint effects of colorectal cancer susceptibility loci, circulating 25-hydroxyvitamin D and risk of colorectal cancer.

PloS one - 1 Jan 2014

Hiraki Linda T, Joshi Amit D, Ng Kimmie, Fuchs Charles S, Ma Jing, Hazra Aditi, Peters Ulrike, Karlson Elizabeth W, Giovannucci Edward, Kraft Peter, Chan Andrew T

Abstract excerpt

BACKGROUND: Genome wide association studies (GWAS) have identified several SNPs associated with colorectal cancer (CRC) susceptibility. Vitamin D is also inversely associated with CRC risk. METHODS: We examined main and joint effects of previously GWAS identified genetic markers of CRC and plasma 25-hydroxyvitamin D (25(OH)D) on CRC risk in three prospective cohorts: the Nurses' Health Study (NHS), the Health...

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Aged
Aged, 80 and over
Case-Control Studies
Colorectal Neoplasms
Genetic Loci

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

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PMID: 24670869
DOI: 10.1371/journal.pone.0092212
PMCID: PMC3966783

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NHS
VDR

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