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Article

Melanocortin 1 receptor-signaling deficiency results in an articular cartilage phenotype and accelerates pathogenesis of surgically induced murine osteoarthritis.

PloS one - 1 Jan 2014

Lorenz Julia, Seebach Elisabeth, Hackmayer Gerit, Greth Carina, Bauer Richard J, Kleinschmidt Kerstin, Bettenworth Dominik, Böhm Markus, Grifka Joachim, Grässel Susanne

Abstract excerpt

Proopiomelanocortin-derived peptides exert pleiotropic effects via binding to melanocortin receptors (MCR). MCR-subtypes have been detected in cartilage and bone and mediate an increasing number of effects in diathrodial joints. This study aims to determine the role of MC1-receptors (MC1) in joint physiology and pathogenesis of osteoarthritis (OA) using MC1-signaling deficient mice (Mc1re/e). OA was surgically...

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Share to Arthritis, Experimental
Share to Cartilage, Articular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Intercellular Adhesion Molecule-1

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Share to Matrix Metalloproteinase 13

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Share to Receptor, Melanocortin, Type 1

Source

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Identifiers

PMID: 25191747
DOI: 10.1371/journal.pone.0105858
PMCID: PMC4156302

Genes

POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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