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Article

In vivo protective effect of adipsin-deficiency on spontaneous knee osteoarthritis in aging mice.

Aging - 1 Feb 2020

Paré Frédéric, Tardif Ginette, Fahmi Hassan, Ouhaddi Yassine, Pelletier Jean-Pierre, Martel-Pelletier Johanne

Abstract excerpt

The adipokine adipsin is an emerging mediator of human osteoarthritis (OA) progression. Here, we investigated its in vivo role in the development of spontaneous OA in aging mice. We compared articular knee joint morphology, histology in knee cartilage, synovial membrane, subchondral bone, meniscus, and anterior cruciate ligament (ACL); and chondrogenesis in the ACL from adipsin-deficient (Df-/-) and wild-type...

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Identifiers

PMID: 32012117
DOI: 10.18632/aging.102784
PMCID: PMC7041762

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