Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor suppressor gene<i><i>PDCD4</i></i>negatively regulates autophagy by inhibiting the expression of autophagy-related gene<i><i>ATG5</i></i>

2 May 2013

Abstract excerpt

PDCD4 (programmed cell death protein 4), a suppressor of gene transcription and translation, plays a crucial inhibitory role in several types of human tumors. However, its underlying mechanisms remain unclear. Autophagy, an evolutionarily conserved catabolic process, maintains cellular homeostasis under stress conditions such as starvation and plays a crucial role in tumor initiation and progression. We report...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cancer-related gene regulation
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23486359
DOI: 10.4161/auto.24069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor suppressor gene<i><i>PDCD4</i></i>negatively regulates autophagy by inhibiting the expression of autophagy-related gene<i><i>ATG5</i></i>PMID 23486359Read ↗

Targeting ATG4 in Cancer TherapySemantic proximity Read ↗

Loss of <i>ATG5</i> expression in a subset of human prostate cancers promotes tumor growth through accumulation of p62Semantic proximity Read ↗

Autophagy as a Target for Non-Immune Intrinsic Functions of Programmed Cell Death-Ligand 1 in CancerSemantic proximity Read ↗

Programmed cell death factor 4 (PDCD4), a novel therapy target for metabolic diseases besides cancerSemantic proximity Read ↗

Tumor-derived PD1 and PD-L1 could promote hepatocellular carcinoma growth through autophagy induction in vitroSemantic proximity Read ↗

A systematic bioinformatics approach for selection of target and screening of ligand for malignant tumours suppressing APG4A gene on Xq22.1.Semantic proximity Read ↗

BIRC5/Survivin is a novel ATG12–ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cellsSemantic proximity Read ↗

Roles of programmed cell death protein 5 in inflammation and cancer (Review)Semantic proximity Read ↗

Comprehensive Pan-Cancer Analysis Confirmed That ATG5 Promoted the Maintenance of Tumor Metabolism and the Occurrence of Tumor Immune EscapeSemantic proximity Read ↗

KDM1A/LSD1 as a promising target in various diseases treatment by regulating autophagy networkSemantic proximity Read ↗

The Role of Death-Associated Protein Kinase-1 in Cell Homeostasis-Related ProcessesSemantic proximity Read ↗

Starvation-induced suppression of DAZAP1 by miR-10b integrates splicing control into TSC2-regulated oncogenic autophagy in esophageal squamous cell carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.