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Article

Platform comparison for evaluation of ALK protein immunohistochemical expression, genomic copy number and hotspot mutation status in neuroblastomas.

PloS one - 1 Jan 2014

Yan Benedict, Kuick Chik Hong, Lim Malcolm, Venkataraman Kavita, Tennakoon Chandana, Loh Eva, Lian Derrick, Leong May Ying, Lakshmanan Manikandan, Tergaonkar Vinay, Sung Wing-Kin, Soh Shui Yen, Chang Kenneth T E

Abstract excerpt

ALK is an established causative oncogenic driver in neuroblastoma, and is likely to emerge as a routine biomarker in neuroblastoma diagnostics. At present, the optimal strategy for clinical diagnostic evaluation of ALK protein, genomic and hotspot mutation status is not well-studied. We evaluated ALK immunohistochemical (IHC) protein expression using three different antibodies (ALK1, 5A4 and D5F3 clones), ALK...

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Identifiers

PMID: 25188507
DOI: 10.1371/journal.pone.0106575
PMCID: PMC4154751

Genes

ALK
CISH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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