Article
High ALK receptor tyrosine kinase expression supersedes ALK mutation as a determining factor of an unfavorable phenotype in primary neuroblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2011
Schulte Johannes H, Bachmann Hagen S, Brockmeyer Bent, Depreter Katleen, Oberthür André, Ackermann Sandra, Kahlert Yvonne, Pajtler Kristian, Theissen Jessica, Westermann Frank, Vandesompele Jo, Speleman Frank, Berthold Frank, Eggert Angelika, Brors Benedikt, Hero Barbara, Schramm Alexander, Fischer Matthias
Abstract excerpt
PURPOSE: Genomic alterations of the anaplastic lymphoma kinase (ALK) gene have been postulated to contribute to neuroblastoma pathogenesis. This study aimed to determine the interrelation of ALK mutations, ALK expression levels, and clinical phenotype in primary neuroblastoma. EXPERIMENTAL DESIGN: The genomic ALK status and global gene expression patterns were examined in 263 primary neuroblastomas....
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