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Article

A semi-dominant mutation in the general splicing factor SF3a66 causes anterior-posterior axis reversal in one-cell stage C. elegans embryos.

PloS one - 1 Jan 2014

Keikhaee Mohammad R, Nash Eric B, O'Rourke Sean M, Bowerman Bruce

Abstract excerpt

Establishment of anterior-posterior polarity in one-cell stage Caenorhabditis elegans embryos depends in part on astral microtubules. As the zygote enters mitosis, these microtubules promote the establishment of a posterior pole by binding to and protecting a cytoplasmic pool of the posterior polarity protein PAR-2 from phosphorylation by the cortically localized anterior polarity protein PKC-3. Prior to...

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PMID: 25188372
DOI: 10.1371/journal.pone.0106484
PMCID: PMC4154684

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