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Article

CYK-4/GAP Provides a Localized Cue to Initiate Anteroposterior Polarity upon Fertilization

27 Jul 2006

Abstract excerpt

The Caenorhabditis elegans anteroposterior axis is established in response to fertilization by sperm. Here we present evidence that RhoA, the guanine nucleotide-exchange factor ECT-2, and the Rho guanosine triphosphatase-activating protein CYK-4 modulate myosin light-chain activity to create a gradient of actomyosin, which establishes the anterior domain. CYK-4 is enriched within sperm, and paternally donated...

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PMID: 16873611
DOI: 10.1126/science.1130291

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Related research

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CYK-4/GAP Provides a Localized Cue to Initiate Anteroposterior Polarity upon FertilizationPMID 16873611Read ↗

The spd-2 gene is required for polarization of the anteroposterior axis and formation of the sperm asters in the Caenorhabditis elegans zygote.Semantic proximity Read ↗

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Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases.Semantic proximity Read ↗

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RhoA activation during polarization and cytokinesis of the early <i>Caenorhabditis elegans</i> embryo is differentially dependent on NOP-1 and CYK-4Semantic proximity Read ↗

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