Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myosin and the PAR proteins polarize microfilament-dependent forces that shape and position mitotic spindles in Caenorhabditis elegans.

The Journal of cell biology - 14 Apr 2003

Severson Aaron F, Bowerman Bruce

Abstract excerpt

In Caenorhabditis elegans, the partitioning proteins (PARs), microfilaments (MFs), dynein, dynactin, and a nonmuscle myosin II all localize to the cortex of early embryonic cells. Both the PARs and the actomyosin cytoskeleton are required to polarize the anterior-posterior (a-p) body axis in one-cell zygotes, but it remains unknown how MFs influence embryonic polarity. Here we show that MFs are required for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bridged Bicyclo Compounds, Heterocyclic
Share to Contractile Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dynactin Complex

Share to Myosin Type II

Share to Nocodazole

Share to Profilins

Share to Thiazolidines

Share to Zygote

Source

Open in PubMed Open full text

Identifiers

PMID: 12695495
DOI: 10.1083/jcb.200210171
PMCID: PMC2172887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myosin and the PAR proteins polarize microfilament-dependent forces that shape and position mitotic spindles in Caenorhabditis elegans.PMID 12695495Read ↗

Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization.Semantic proximity Read ↗

The spd-2 gene is required for polarization of the anteroposterior axis and formation of the sperm asters in the Caenorhabditis elegans zygote.Semantic proximity Read ↗

PAR-2, LGL-1 and the CDC-42 GAP CHIN-1 act in distinct pathways to maintain polarity in the C. elegans embryo.Semantic proximity Read ↗

PAR-dependent and geometry-dependent mechanisms of spindle positioning.Semantic proximity Read ↗

Symmetry breaking and polarization of the C. elegans zygote by the polarity protein PAR-2.Semantic proximity Read ↗

PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos.Semantic proximity Read ↗

Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases.Semantic proximity Read ↗

The PAR proteins: fundamental players in animal cell polarization.Semantic proximity Read ↗

PAR-3 and PAR-1 inhibit LET-99 localization to generate a cortical band important for spindle positioning in Caenorhabditis elegans embryos.Semantic proximity Read ↗

Mutations in the par genes of Caenorhabditis elegans affect cytoplasmic reorganization during the first cell cycle.Semantic proximity Read ↗

Polar relaxation by dynein-mediated removal of cortical myosin II.Semantic proximity Read ↗

PAR-4/LKB1 mobilizes nonmuscle myosin through anillin to regulate C. elegans embryonic polarization and cytokinesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.