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Article

Mutation screen of LOXL1 in patients with female pelvic organ prolapse.

Female pelvic medicine & reconstructive surgery - 1 Jan 2000

Neupane Ruel, Sadeghi Zhina, Fu Rao, Hagstrom Stephanie A, Moore Courtenay K, Daneshgari Firouz

Abstract excerpt

OBJECTIVES: The LOXL1 (lysyl oxidase-like 1) gene encodes a copper-dependent monoamine oxidase that catalyzes the deamination of a lysine residue in the cross-linking of tropoelastin monomers to form elastin. LOXL1-KO mice do not deposit normal elastic fibers in their genitourinary tract resulting in postpartum pelvic organ prolapse and lower urinary tract dysfunction with decreased bladder capacity and lower...

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Source

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Identifiers

PMID: 25185627
DOI: 10.1097/SPV.0000000000000108
PMCID: PMC4263899

Genes

LOXL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutation screen of LOXL1 in patients with female pelvic organ prolapse.PMID 25185627Read ↗

Lower urogenital tract anatomical and functional phenotype in lysyl oxidase like-1 knockout mice resembles female pelvic floor dysfunction in humans.Semantic proximity Read ↗

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TT polymorphism in rs2165241 and rs1048661 region in lysyl oxidase like-1 gene may have a role in stress urinary incontinence physiopathology.Semantic proximity Read ↗

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Structural, functional and molecular pathogenesis of pelvic organ prolapse in patient and Loxl1 deficient miceSemantic proximity Read ↗

[Elastogenesis-Related Gene Polymorphisms and the Risk of Pelvic Organ Prolapse Development].Semantic proximity Read ↗

Comprehensive analysis of LAMC1 genetic variants in advanced pelvic organ prolapse.Semantic proximity Read ↗

Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice.Semantic proximity Read ↗

Deletion of the lysyl oxidase-like 1 gene induces impaired elastin fiber synthesis and inefficient urethral closure in rats.Semantic proximity Read ↗

Collagen XVIII and LOXL-4 polymorphisms in women with and without advanced pelvic organ prolapse.Semantic proximity Read ↗

Sequence variant in the laminin gamma1 (LAMC1) gene associated with familial pelvic organ prolapse.Semantic proximity Read ↗

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