Sequence variant in the laminin gamma1 (LAMC1) gene associated with familial pelvic organ prolapse.

Abstract excerpt

Pelvic organ prolapse is a common condition, affecting up to a third of women throughout their lifetime. Genetic factors are believed to account for about 30% of the incidence, and are the least understood component of the disorder. Familial cases, particularly those in which prolapse manifests in young women, are especially valuable in the effort to find the genes involved. We recently reported autosomal...

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