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Article

Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice.

Circulation - 5 Nov 2002

Mäki Joni M, Räsänen Juha, Tikkanen Hilkka, Sormunen Raija, Mäkikallio Kaarin, Kivirikko Kari I, Soininen Raija

Abstract excerpt

BACKGROUND: The lysyl oxidases are extracellular copper enzymes that initiate the crosslinking of collagens and elastin, 5 human isoenzymes having been characterized so far. The crosslinks formed provide the tensile strength and elastic properties for various extracellular matrices, including vas...

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Source

Identifiers

PMID: 12417550
DOI: 10.1161/01.cir.0000038109.84500.1e

Genes

LOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12417550-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice.PMID 12417550Read ↗

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Role of the lysyl oxidase enzyme family in cardiac function and diseaseSemantic proximity Read ↗

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