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Article

A single nucleotide polymorphism in the promoter of the LOXL1 gene and its relationship to pelvic organ prolapse and preterm premature rupture of membranes.

Reproductive sciences (Thousand Oaks, Calif.) - 1 May 2009

Ferrell Georgia, Lu Minyan, Stoddard Paul, Sammel Mary D, Romero Roberto, Strauss Jerome F, Matthews Catherine A

Abstract excerpt

Pelvic organ prolapse and preterm premature rupture of membranes, the 2 conditions which have in common weakening of the tensile strength of tissues, are thought to be caused, in part, by abnormal extracellular matrix synthesis and/or catabolism. We identified a new single nucleotide polymorphism (NT_010194(LOXL1):g.45008784A>C) in the promoter of the LOXL1 gene, which is essential for elastin synthesis. Promoter...

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Identifiers

PMID: 19182211
DOI: 10.1177/1933719108330567
PMCID: PMC2668743

Genes

LOXL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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