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Article

Structure-resolved dynamics of type 2M von Willebrand disease.

Journal of thrombosis and haemostasis : JTH - 1 Apr 2025

Tischer Alexander, Moon-Tasson Laurie, Auton Matthew

Abstract excerpt

BACKGROUND: Genetically determined amino acid substitutions in the platelet adhesive A1 domain alter von Willebrand factor's (VWF) platelet agglutination competence, resulting in both gain- (type 2B) and loss-of-function (type 2M) phenotypes of von Willebrand disease. Prior studies of variants in both phenotypes revealed defects in secondary structure that altered stability and folding of the domain. An...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39756657
DOI: 10.1016/j.jtha.2024.12.026
PMCID: PMC11972889

Genes

VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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