Article

Thermodynamic stabilization of the von Willebrand Factor A1 domain due to loss-of-function disease-related mutations

2022-03-11

Abstract excerpt

The von Willebrand disease (vWD) is the most common hereditary bleeding disorder, caused by defects of the von Willebrand Factor (vWF), a large extracellular protein in charge of adhering platelets at sites of vascular lesion. vWF carries out this essential homeostatic task, via the specific protein-protein interaction between the vWF A1 domain and the platelet receptor, the glycoprotein Ib alpha (GPIB α ). Upon...

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Literature Corpus work: ac9bd77f-f2a2-5332-9166-1aaf190b063d
DOI: 10.1101/2022.03.10.483861

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