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Article

Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module.

Nature communications - 21 Apr 2021

Arce Nicholas A, Cao Wenpeng, Brown Alexander K, Legan Emily R, Wilson Moriah S, Xu Emma-Ruoqi, Berndt Michael C, Emsley Jonas, Zhang X Frank, Li Renhao

Abstract excerpt

Von Willebrand factor (VWF) activates in response to shear flow to initiate hemostasis, while aberrant activation could lead to thrombosis. Above a critical shear force, the A1 domain of VWF becomes activated and captures platelets via the GPIb-IX complex. Here we show that the shear-responsive element controlling VWF activation resides in the discontinuous autoinhibitory module (AIM) flanking A1. Application of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33883551
DOI: 10.1038/s41467-021-22634-x
PMCID: PMC8060278

Genes

VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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