Article

Natural variants of von Willebrand factor R1205 causing von Willebrand disease with accelerated von Willebrand factor clearance: <i>in silico</i> docking models and energetics of the interaction with both LRP1 and GpIb A1 domain

2025-08-22

Abstract excerpt

Type 1 von Willebrand disease (VWD) is often caused by variants in von Willebrand factor (VWF), including p.R1205H (“Vicenza mutation”), which accelerate VWF clearance via macrophage receptor LRP1 and impair platelet adhesion. However, the structural mechanisms underlying these phenotypes remain unclear. Here, we use integrative computational modeling (I-TASSER, HADDOCK2.4, and PRODIGY) to predict how p.R1205H/C/L...

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Literature Corpus work: 22cb5c0d-12df-53b4-9062-58249d9e66d8
DOI: 10.1101/2025.08.22.671727

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Natural variants of von Willebrand factor R1205 causing von Willebrand disease with accelerated von Willebrand factor clearance: <i>in silico</i> docking models and energetics of the interaction with both LRP1 and GpIb A1 domainDOI 10.1101/2025.08.22.671727Read

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