Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.

doi:10.1038/ng.311

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.

Nature genetics - 1 Feb 2009

Nair Rajan P, Duffin Kristina Callis, Helms Cynthia, Ding Jun, Stuart Philip E, Goldgar David, Gudjonsson Johann E, Li Yun, Tejasvi Trilokraj, Feng Bing-Jian, Ruether Andreas, Schreiber Stefan, Weichenthal Michael, Gladman Dafna, Rahman Proton, Schrodi Steven J, Prahalad Sampath, Guthery Stephen L, Fischer Judith, Liao Wilson, Kwok Pui-Yan, Menter Alan, Lathrop G Mark, Wise Carol A, Begovich Ann B, Voorhees John J, Elder James T, Krueger Gerald G, Bowcock Anne M, Abecasis Gonçalo R

Abstract excerpt

Psoriasis is a common immune-mediated disorder that affects the skin, nails and joints. To identify psoriasis susceptibility loci, we genotyped 438,670 SNPs in 1,409 psoriasis cases and 1,436 controls of European ancestry. We followed up 21 promising SNPs in 5,048 psoriasis cases and 5,041 controls. Our results provide strong support for the association of at least seven genetic loci and psoriasis (each with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to NF-kappa B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-C Antigens

Share to Interleukin-12 Subunit p40

Share to Interleukin-13

Share to Interleukin-23

Share to Interleukin-4

Share to Psoriasis

Share to Tumor Necrosis Factor alpha-Induced Protein 3

Source

Open in PubMed Open full text

Identifiers

PMID: 19169254
DOI: 10.1038/ng.311
PMCID: PMC2745122

Genes

TNF
TNFAIP3
TNIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.PMID 19169254Read ↗

Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis.Semantic proximity Read ↗

The immunogenetics of Psoriasis: A comprehensive review.Semantic proximity Read ↗

The Pathogenesis and Genetics of PsoriasisSemantic proximity Read ↗

Fine mapping of eight psoriasis susceptibility loci.Semantic proximity Read ↗

Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci.Semantic proximity Read ↗

Meta-analysis of the TNFAIP3 region in psoriasis reveals a risk haplotype that is distinct from other autoimmune diseases.Semantic proximity Read ↗

Association with Genetic Variants in the IL-23 and NF-κB Pathways Discriminates between Mild and Severe Psoriasis Skin Disease.Semantic proximity Read ↗

Molecular dissection of psoriasis: integrating genetics and biology.Semantic proximity Read ↗

A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.Semantic proximity Read ↗

Unraveling the genetics of complex diseases: susceptibility genes for rheumatoid arthritis and psoriasis.Semantic proximity Read ↗

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.Semantic proximity Read ↗

Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.