Article
MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes.
The Journal of clinical investigation - 1 Oct 2014
Sachdeva Mohit, Mito Jeffrey K, Lee Chang-Lung, Zhang Minsi, Li Zhizhong, Dodd Rebecca D, Cason David, Luo Lixia, Ma Yan, Van Mater David, Gladdy Rebecca, Lev Dina C, Cardona Diana M, Kirsch David G
Abstract excerpt
Metastasis causes most cancer deaths, but is incompletely understood. MicroRNAs can regulate metastasis, but it is not known whether a single miRNA can regulate metastasis in primary cancer models in vivo. We compared the expression of miRNAs in metastatic and nonmetastatic primary mouse sarcomas and found that microRNA-182 (miR-182) was markedly overexpressed in some tumors that metastasized to the lungs. By...
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