Article
Local microRNA delivery targets Palladin and prevents metastatic breast cancer.
Nature communications - 19 Sept 2016
Gilam Avital, Conde João, Weissglas-Volkov Daphna, Oliva Nuria, Friedman Eitan, Artzi Natalie, Shomron Noam
Abstract excerpt
Metastasis is the primary cause for mortality in breast cancer. MicroRNAs, gene expression master regulators, constitute an attractive candidate to control metastasis. Here we show that breast cancer metastasis can be prevented by miR-96 or miR-182 treatment, and decipher the mechanism of action. We found that miR-96/miR-182 downregulate Palladin protein levels, thereby reducing breast cancer cell migration and...
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