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Article

Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases.

Cancer research - 15 Jun 2006

Houghton A McGarry, Grisolano Jay L, Baumann Mary L, Kobayashi Dale K, Hautamaki R Dean, Nehring Leslie C, Cornelius Lynn A, Shapiro Steven D

Abstract excerpt

Matrix metalloproteinases (MMP) have been implicated in virtually all aspects of tumor progression. However, the recent failure of clinical trials employing synthetic MMP inhibitors in cancer chemotherapy has led us to hypothesize that some MMPs may actually serve the host in its defense against tumor progression. Here we show that mice deficient in macrophage elastase (MMP-12) develop significantly more gross...

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Source

Identifiers

PMID: 16778188
DOI: 10.1158/0008-5472.CAN-04-0297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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