Article
miR-155, identified as anti-metastatic by global miRNA profiling of a metastasis model, inhibits cancer cell extravasation and colonization in vivo and causes significant signaling alterations.
Oncotarget - 6 Oct 2015
Thomsen Karina G, Terp Mikkel G, Lund Rikke R, Søkilde Rolf, Elias Daniel, Bak Martin, Litman Thomas, Beck Hans C, Lyng Maria B, Ditzel Henrik J
Abstract excerpt
To gain insight into miRNA regulation in metastasis formation, we used a metastasis cell line model that allows investigation of extravasation and colonization of circulating cancer cells to lungs in mice. Using global miRNA profiling, 28 miRNAs were found to exhibit significantly altered expression between isogenic metastasizing and non-metastasizing cancer cells, with miR-155 being the most differentially...
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