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Article

LIM kinase‐2 targeting as a possible anti‐metastasis therapy

30 Jan 2004

Abstract excerpt

BACKGROUND: Metastatic properties of tumors involve movement of cancerous cells from one place to another and tissue invasion. Metastatic cells have altered cell adhesion and movement that can be examined by in vitro chemotaxis assays. The Rho/ROCK/LIM kinase pathway is one of the major signaling pathways involved in tumor metastasis. It is involved in the regulation of the actin cytoskeleton. Using the...

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PMID: 15026997
DOI: 10.1002/jgm.491

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