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Article

Targeted disruption of CD44 in MDAY-D2 lymphosarcoma cells has no effect on subcutaneous growth or metastatic capacity.

The Journal of cell biology - 1 Dec 1995

Driessens M H, Stroeken P J, Rodriguez Erena N F, van der Valk M A, van Rijthoven E A, Roos E

Abstract excerpt

CD44 splice variants have been shown to be involved in metastasis of carcinomas. In addition, the standard form of CD44 has been implicated in metastasis, particularly of melanomas and lymphomas. To investigate this, we have generated a CD44-negative mutant of the highly metastatic murine MDAY-D2 lymphosarcoma. The two CD44 alleles of this diploid cell line were sequentially disrupted by homologous recombination,...

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Identifiers

PMID: 8557751
DOI: 10.1083/jcb.131.6.1849
PMCID: PMC2120664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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