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Article

Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus

1 Sept 2014

Abstract excerpt

Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by the production of antibodies to self-nucleic acids, immune complex deposition, and tissue inflammation such as glomerulonephritis. Innate recognition of self-DNA and -RNA and the ensuing production of cytokines such as type I interferons (IFNs) contribute to SLE development. Plasmacytoid dendritic cells (pDCs) have been proposed as a...

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PMID: 25180061
DOI: 10.1084/jem.20132522

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