Plasmid copy number underlies adaptive mutability in bacteria.

doi:10.1534/genetics.114.170068

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Article

Plasmid copy number underlies adaptive mutability in bacteria.

Genetics - 1 Nov 2014

Sano Emiko, Maisnier-Patin Sophie, Aboubechara John Paul, Quiñones-Soto Semarhy, Roth John R

Abstract excerpt

The origin of mutations under selection has been intensively studied using the Cairns-Foster system, in which cells of an Escherichia coli lac mutant are plated on lactose and give rise to 100 Lac+ revertants over several days. These revertants have been attributed variously to stress-induced mutagenesis of nongrowing cells or to selective improvement of preexisting weakly Lac+ cells with no mutagenesis. Most...

Topics

Adaptation, Biological
DNA Copy Number Variations
Escherichia coli
Gene Amplification
Gene Dosage
Gene Duplication
Genes, Bacterial
Lac Operon
Mutagenesis, Insertional
Mutation
Plasmids
Salmonella typhimurium
Tetracyclines

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Identifiers

PMID: 25173846
DOI: 10.1534/genetics.114.170068
PMCID: PMC4224180

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