Article
Adaptive amplification and point mutation are independent mechanisms: evidence for various stress-inducible mutation mechanisms.
PLoS biology - 1 Dec 2004
Hastings P J, Slack Andrew, Petrosino Joseph F, Rosenberg Susan M
Abstract excerpt
"Adaptive mutation" denotes a collection of processes in which cells respond to growth-limiting environments by producing compensatory mutants that grow well, apparently violating fundamental principles of evolution. In a well-studied model, starvation of stationary-phase lac(-)Escherichia coli cells on lactose medium induces Lac(+)revertants at higher frequencies than predicted by usual mutation models. These...
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