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Article

The amplification model for adaptive mutation: simulations and analysis.

Genetics - 1 Feb 2005

Pettersson Mats E, Andersson Dan I, Roth John R, Berg Otto G

Abstract excerpt

It has been proposed that the lac revertants arising under selective conditions in the Cairns experiment do not arise by stress-induced mutagenesis of stationary phase cells as has been previously assumed. Instead, these revertants may arise within growing clones initiated by cells with a preexisting duplication of the weakly functional lac allele used in this experiment. It is proposed that spontaneous stepwise...

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Identifiers

PMID: 15489536
DOI: 10.1534/genetics.104.030338
PMCID: PMC1449099

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