Article
A High-Resolution View of Adaptive Event Dynamics in a Plasmid.
Genome biology and evolution - 1 Oct 2019
Mei Han, Arbeithuber Barbara, Cremona Marzia A, DeGiorgio Michael, Nekrutenko Anton
Abstract excerpt
Coadaptation between bacterial hosts and plasmids frequently results in adaptive changes restricted exclusively to host genome leaving plasmids unchanged. To better understand this remarkable stability, we transformed naïve Escherichia coli cells with a plasmid carrying an antibiotic-resistance gene and forced them to adapt in a turbidostat environment. We then drew population samples at regular intervals and...
Topics
- DNA Copy Number Variations
- Escherichia coli
- Evolution, Molecular
- Genetic Variation
- Mutation
- Plasmids
- Sequence Analysis, DNA