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Article

Adaptive amplification: an inducible chromosomal instability mechanism.

Cell - 22 Nov 2000

Hastings P J, Bull H J, Klump J R, Rosenberg S M

Abstract excerpt

Adaptive mutation is an induced response to environmental stress in which mutation rates rise, producing permanent genetic changes that can adapt cells to stress. This contrasts with neo-Darwinian views of genetic change rates blind to environmental conditions. DNA amplification is a flexible, reversible genomic change that has long been postulated to be adaptive. We report the discovery of adaptive amplification...

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PMID: 11114329
DOI: 10.1016/s0092-8674(00)00176-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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