Article
Gene amplification mutations originate prior to selective stress in Acinetobacter baylyi.
G3 (Bethesda, Md.) - 9 Mar 2023
Herrmann Jennifer A, Koprowska Agata, Winters Tesa J, Villanueva Nancy, Nikityuk Victoria D, Pek Feini, Reis Elizabeth M, Dominguez Constancia Z, Davis Daniel, McPherson Eric, Rocco Staci R, Recendez Cynthia, Difuntorum Shyla M, Faeth Kelly, Lopez Mario D, Awwad Habeeba M, Ghobashy Rola A, Cappiello Lauren, Neidle Ellen L, Quiñones-Soto Semarhy, Reams Andrew B
Abstract excerpt
The controversial theory of adaptive amplification states gene amplification mutations are induced by selective environments where they are enriched due to the stress caused by growth restriction on unadapted cells. We tested this theory with three independent assays using an Acinetobacter baylyi model system that exclusively selects for cat gene amplification mutants. Our results demonstrate all cat gene...
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