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Article

The Origin of Mutants Under Selection: How Natural Selection Mimics Mutagenesis (Adaptive Mutation).

Cold Spring Harbor perspectives in biology - 1 Jul 2015

Maisnier-Patin Sophie, Roth John R

Abstract excerpt

Selection detects mutants but does not cause mutations. Contrary to this dictum, Cairns and Foster plated a leaky lac mutant of Escherichia coli on lactose medium and saw revertant (Lac(+)) colonies accumulate with time above a nongrowing lawn. This result suggested that bacteria might mutagenize their own genome when growth is blocked. However, this conclusion is suspect in the light of recent evidence that...

Topics

Escherichia coli
Mutagenesis
Mutation
Selection, Genetic
Stress, Physiological

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 26134316
DOI: 10.1101/cshperspect.a018176
PMCID: PMC4484973

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