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Article

Mechanisms of mutation in nondividing cells. Insights from the study of adaptive mutation in Escherichia coli.

Annals of the New York Academy of Sciences - 18 May 1999

Foster P L, Rosche W A

Abstract excerpt

When populations of cells are subjected to nonlethal selection, mutations arise in the absence of cell division, a phenomenon that has been called "adaptive mutation." In a strain of Escherichia coli that cannot metabolize lactose (Lac-) but that reverts to lactose utilization (Lac+) when lactose is its sole energy and carbon source, the mutational process consists of two components. (1) A highly efficient,...

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Identifiers

PMID: 10415479
DOI: 10.1111/j.1749-6632.1999.tb08873.x
PMCID: PMC2928472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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