Article
PREVALENCE OF CELIAC DISEASE PREDISPOSING GENOTYPES, INCLUDING HLA-DQ2.2 VARIANT, IN BRAZILIAN CHILDREN.
Arquivos de gastroenterologia - 1 Jan 2000
Selleski Nicole, Almeida Lucas Malta, Almeida Fernanda Coutinho de, Pratesi Claudia Beatriz, Nóbrega Yanna Karla de Medeiros, Gandolfi Lenora
Abstract excerpt
BACKGROUND: Celiac disease is an autoimmune enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Almost all celiac patients carry immune recognition genes coding for HLA-DQ2.5 and DQ8 heterodimers. Over the last few years, great importance has been given to HLA-DQ2.2 as probable predisposing variant, although controversies still exist regarding its relevance. OBJECTIVE: The aim...
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