Article
Lack of the NS5B S282T mutation in HCV isolates from liver tissue of treatment-naive patients with HCV genotype-1b infection.
Antiviral therapy - 1 Jan 2015
Maimone Sergio, Tripodi Gianluca, Musolino Cristina, Cacciola Irene, Pollicino Teresa, Raimondo Giovanni
Abstract excerpt
BACKGROUND: Despite the availability of several direct-acting antivirals (DAAs) specifically inhibiting different HCV proteins, treatment of chronic HCV infection is still a challenge also because of the possible selection of resistant viral variants under DAA therapy. Indeed, only the emergence of viruses resistant to the nucleoside inhibitors of the HCV NS5B polymerase (Pol) has not yet been reported, in spite...
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