Article
Association of hepatitis C virus NS5B variants with resistance to new antiviral drugs among untreated patients.
Memorias do Instituto Oswaldo Cruz - 1 Dec 2011
Castilho Magda Cristina Bernardino, Martins Angélica Nascimento, Horbach Ingrid Siciliano, Perez Renata de Mello, Figueiredo Fatima Aparecida Ferreira, Pinto Paulo de Tarso Aparecida, Nabuco Leticia Cancela, Lima Dirce Bonfim de, Tanuri Amílcar, Porto Luis Cristóvão, Ferreira Júnior Orlando da Costa
Abstract excerpt
Mutations located in the 109-amino acid fragment of NS5B are typically associated with resistance to interferon (IFN) and ribavirin (RIB) and to new antiviral drugs. The prevalence of these mutations was examined in 69 drug-naïve individuals with hepatitis C virus (HCV) infections in Rio de Janeiro, Brazil. Mutations related to non-response to IFN/RIB were observed in all subtypes studied (1a, 1b, 2b, 3a and 4)....
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