Article
Naturally occurring substitutions conferring resistance to hepatitis C virus polymerase inhibitors in treatment-naive patients infected with genotypes 1-5.
Antiviral therapy - 1 Jan 2009
Legrand-Abravanel Florence, Henquell Cécile, Le Guillou-Guillemette Hélène, Balan Viorica, Mirand Audrey, Dubois Martine, Lunel-Fabiani Francoise, Payan Christopher, Izopet Jacques
Abstract excerpt
BACKGROUND: The hepatitis C virus (HCV) RNA-dependent RNA polymerase, NS5B, is essential for virus RNA replication. It is thus an attractive therapeutic target. Several compound nucleoside analogues, non-nucleoside inhibitors and cyclosporine analogues are being developed to inhibit NS5B activity. However, nucleotide changes in the NS5B gene can confer resistance to them. METHODS: We investigated the prevalence...
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