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Article

No detection of the NS5B S282T mutation in treatment-naïve genotype 1 HCV/HIV-1 coinfected patients using deep sequencing.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Dec 2013

Franco Sandra, Casadellà Maria, Noguera-Julian Marc, Clotet Bonaventura, Tural Cristina, Paredes Roger, Martinez Miguel Angel

Abstract excerpt

BACKGROUND: The S282T mutation is the main variant described associated with resistance to nucleos(t)ide analogues hepatitis C virus (HCV) NS5B polymerase inhibitors. OBJECTIVE: We aimed here to investigate whether this substitution pre-existed in treatment naive HCV/HIV-1 coinfected patients. STUDY DESIGN: NS5B polymerase deep sequencing was performed at a median coverage per base of 4471 in 16 patient samples....

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Source

Identifiers

PMID: 24140031
DOI: 10.1016/j.jcv.2013.09.022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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