Article
Integrity of the NS5A (amino acid 2209 to 2248) region in hepatitis C virus 1b patients non-responsive to interferon therapy.
Liver - 1 Oct 2000
Halfon P, Halimi G, Bourlière M, Ouzan D, Durant J, Khiri H, Mercier L, Gerolami V, Cartouzou G
Abstract excerpt
BACKGROUND/AIMS: In hepatitis C virus-1b, it has been suggested that an amino acid stretch (aa 2209-2248) of the carboxy terminal half of the non-structural 5A (NS5A) region participates in the response to interferon treatment. We tested the hypothesis that absence of mutations in the NS5A (aa 2209-2248) sequence is required for interferon resistance. We also investigated the importance of different HCV-1b...
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