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Article

Identification of HCV Resistant Variants against Direct Acting Antivirals in Plasma and Liver of Treatment Naïve Patients.

Scientific reports - 5 Jul 2017

Raj V Stalin, Hundie Gadissa Bedada, Schürch Anita C, Smits Saskia L, Pas Suzan D, Le Pogam Sophie, Janssen Harry L A, de Knegt Rob J, Osterhaus Albert D M E, Najera Isabel, Boucher Charles A, Haagmans Bart L

Abstract excerpt

Current standard-of-care treatment of chronically infected hepatitis C virus (HCV) patients involves direct-acting antivirals (DAA). However, concerns exist regarding the emergence of drug -resistant variants and subsequent treatment failure. In this study, we investigate potential natural drug-resistance mutations in the NS5B gene of HCV genotype 1b from treatment-naïve patients. Population-based sequencing and...

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Share to Antiviral Agents
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hepatitis C, Chronic

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Share to Sequence Analysis, RNA

Share to Viral Nonstructural Proteins

Source

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Identifiers

PMID: 28680115
DOI: 10.1038/s41598-017-04931-y
PMCID: PMC5498547

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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