Article
NS3 genetic variability in HCV genotype-1b isolates from liver specimens and blood samples of treatment-naive patients with chronic hepatitis C.
Antiviral therapy - 1 Jan 2013
Maimone Sergio, Musolino Cristina, Squadrito Giovanni, Raffa Giuseppina, Pollicino Teresa, Raimondo Giovanni
Abstract excerpt
BACKGROUND: Two distinct inhibitors of the HCV protease have been approved for the treatment of patients infected with HCV genotype-1. These drugs are highly efficient in suppressing HCV replication; however, their use is limited by the emergence of viral mutants resistant to them after a very short time of treatment. By analysing blood samples, it was shown that viral strains resistant to protease inhibitors...
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