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Article

Prevalence of natural polymorphisms at the HCV NS5A gene associated with resistance to daclatasvir, an NS5A inhibitor.

Antiviral therapy - 1 Jan 2012

Plaza Zulema, Soriano Vincent, Vispo Eugenia, del Mar Gonzalez Maria, Barreiro Pablo, Seclén Eduardo, Poveda Eva

Abstract excerpt

BACKGROUND: Daclatasvir (BMS-790052) is an investigational molecule that inhibits the HCV NS5A protein and shows potent antiviral activity apparently across all HCV genotypes. Selection of drug resistance mutations has been reported only for HCV genotype 1, and no information exists for other HCV variants and/or in HIV-HCV-coinfected individuals. METHODS: All interferon-α-naive, HIV-HCV-coinfected patients newly...

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Identifiers

PMID: 22436385
DOI: 10.3851/IMP2091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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