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Article

Association of a functional polymorphism in the promoter region of TLR-3 with osteoarthritis: a two-stage case-control study.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 May 2013

Yang Hsin-Yi, Lee Herng-Sheng, Lee Chian-Her, Fang Wen-Hui, Chen Hsiang-Cheng, Salter Donald M, Su Sui-Lung

Abstract excerpt

Recent studies have suggested that polymorphisms in toll-like receptor 9 (TLR-9), an endosomal TLR, are associated with knee osteoarthritis (OA). TLR-3, -7, and -8 are also found on the surface of endosomes and to investigate whether similar associations exist with polymorphisms in these TLR genes we performed a two-stage case-control study and genotyped 11 TLR single nucleotide polymorphisms (SNPs) in 823 OA...

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Source

Identifiers

PMID: 23255072
DOI: 10.1002/jor.22291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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